Most efficient Setup for getting things done?

It would be helpful to know specifically where you think you might be wasting time and effort. Otherwise, we're guessing. the only thing we could tell you is what we do and what we like, which may or may not be relevant. Also, if you switch to MacOS, there is a learning curve. You would have to invest time and energy to learn before you can start using and only then would you begin to learn where you are inefficient, which itself might simply be the result of using a new operating system.

I use ulysses on mac for long form writing as, pretty much every other text editor is either completely lacking in professional grade tools and standards, or has issues with accessibility.

I have a mac mini running libation, which downloads both my audible UK and US books, and audio bookshelf server. This means I can combine audio book libraries to access on the go as well as adding hard to find audiobooks from places like the RNIB. It uses google books to grab the meta data, which is great. It's still in its infancy and requires docker to get it set up, but once it is, everything appears automatically after book purchase in Prologue Beta.

Oh, also, to access my mac mini, which is my home serve, I use TaleScale and screen sharing on mac 26, which are both very accessible.

How accessible is the Fairphone, and what are its advantages?

Hi Dennis,
I know this might be stating the obvious, and you probably know this anyway, but I'm just throwing it out there, but the faster your screen reader speech, the quicker you'll be at doing stuff. I've sseen people have their speech at about %20, and I wonder how on earth they get things done quickly and efficiently. I have /NVDA with Eloquence on Windows set to %45, and my Apple devices with VoiceOver set to about %65. These speeds would still be considered slow by some, but it's still quicker than everything at about %20. When I was doing proofreading work on Windows a few years ago, I used to speed up my Eloquence to about %65 or more sometimes, because the quicker I could read stuff, the quicker I could correct things and get the work done. Learn as many system-wide and screen reader specific keyboard shortcuts as you can, both for Windows and Mac. The more keyboard shortcuts you know, the quicker you'll get things done. I wouldn't personally get this myself, but check out Leasey for JAWS from Brian Hartgen.
https://hartgen.org/leaseycentral
Leasey is basically a platform in conjunction with JAWS that provides shortcuts for doing different things. Personally I'm happy with NVDA as my daily driver, but it's just a suggestion. If you can give us a specific scenario where you feel you're not as fast as you want to be, then maybe people can give you better suggestions.

I have a Windows 11 laptop from HP as well as an Xbox, both of which I gain on quite regularly. I have both Xbox titles that are, "play anywhere titles", as well as PC exclusive games. I probably spend more time gaming on the laptop, than I do on the Xbox with the inclusion of the "play anywhere" titles plus GamePass. Primarily, I play fighting games, but I dabble a little bit with Forza Motorsports for Xbox. Sadly though, racing games just don't hold my interest for very long anymore. Fighting games, however, will never die. I also have my iPhone connected to my PC via Phone Link, which benefits me very well for file sharing purposes. Everything else is connected to Alexa. I also have a fire TV, so if I want to watch YouTube, for example, I just tell my Alexa device to play something on YouTube on my fire TV. If I want to schedule an event on my iCloud calendar, that two is connected to Alexa, so I can do it all through my Alexa device as well.

With Audible and Kindle both being part of the Amazon family, I can have my Alexa device also play any of my books, both Audible and e-book versions, through my Alexa device. Alternatively, I can do the same with the Alexa app on my iPhone.
Basically if it can be connected to Alexa, it is connected to Alexa. 😀

I do absolutely everything on my iPhone. My writing is done in the Ulysses app. I use the Notes app and have come to really appreciate the quicknotes feature. I have the action button set to quicknote so I can quickly type or dictate a new note and then save it if I end up wanting to keep it or cancel if not. That gets rid of empty notes which used to bug me if I decide I don't ultimately need to keep something jotted down in a hurry. Smart folders and hashtags keep it all nicely organized. I use Gmail and the Gmail app to handle all email.
I use a Bluetooth keyboard for typing but tend to use the screen gestures rather than keyboard commands when navigating, editing, spellchecking, etc. All of my books are on my iPhone. I use Kindle, Audible, and Voice Dream Reader for the majority of my reading.
The biggest advantage is that it's aways with you and there's less hassle if it's all on one device. You can pick and choose when to carry, upgrade and use accessories like keyboards, Bluetooth speakers, etc.
If you're employed, you need to take what your business uses. this might make it impossible or less optimal to stick exclusively to your iPhone to get things done. Certain hobbies might also benefit from having a PC as well. This is the case for my wife. However, I've honestly not missed Windows in the slightest when it comes to productivity. There are a fe things I wish Apple would streamline. For one, there should be an option to have audio ducking not duck the volume of phone conversations. I have to quickly turn off ducking to fix that. Also, there really should be chime options in the Clock app. There may be other gripes which aren't coming to me off the top of my head, but I've been pretty happy on the whole.

Ah, now that is a question I can answer. I have an iPhone 15 pro with 512gb and a Mac Studio with M1 ultra with 128gb random access memory and 4tb internal ssd.

My wife has an iPad and her own iPhone 15 Pro. We are networked via wi-fi and sync with icloud.com. All automatic. I also backup to a couple 18tb hard drives using time machine, also all automatic.

For my Mac I use an Apple keyboard with touch id, but I'm not happy with it and am thinking of going back to a mechanical keyboard. Too many typos on the Apple keyboard. I don't do much text entry these days, though, except emails and posts. Most of my hard core use of my computer is for composing music using Sibelius Ultimate, and producing music (recording, mixing and mastering) using Logic Pro and a host of plug ins etc.

I left windows 12 years ago because it had too many issues.

Hope this helps.

Good to know about fairphone accessibility! Thank you. It's a shame that the more privacy conscious forks of android like graphine are literally not accessible as they remove everything google from it including the accessibility suite...