Setting Up a Mac Mini for Low Vision

Hi there!
Using zoom on the Mac is a must have if you are low vision to do that, simply open system settings by clicking on the apple menu on the top left corner of your screen.
On the left side of system settings, click on Accessibility. Once that's highlighted, look for zoom on the right.
It's below VoiceOver.
Once in the Zoom settings, toggle on use keyboard shortcuts to zoom.
Once enabled. you could use option+command+= to zoom in and option+command+- to zoom out.
For my use case, I have always been using the full screen zoom as I found that to be the most helpful.
Next is turning on dark mode through out the OS. The settings to do that is in the Appearance settings.
I have also downloaded a extension called night fall on both my Mac and iPhone so that all the website i visit have a dark background and white text similar to my OS which has dark mode turned on at all times.
To get the extension click on the link provided below.
https://apps.apple.com/sg/app/nitefall-browser-dark-mode/id1575190591 there is a small fee if you want full functionality but, I think it's worth it as So far, it has never failed
another function i would like you to try is stage manager (toggle for it is located in desktop & Doc settings) with this feature enabled, only one window is displayed on screen at a time.

Personally, I am not using this feature as I have a programme in full screen most of the time.
To full screen a program., simply press on the green button on the left hand corner of the opened window.
There is actually no one size fits all solution when it comes to customising Mac for a low vision user as what works for me might not wirk for you such as I need full screen zoom on the mac but you might only need picture in picture zoom.
So exploring the Accessibility settings is key to find out what works best for you.
Oh and one more suggestion, it might help to buy different coloured stickers and paste them on your keyboard as it will make locating frequently used keys easier.
I hope my comment is able to help you in some way.
🙂

I don’t recommend you colorcode your keyboard, keyboards are pretty easy to memorize, especially since most our standardized. This means faster typing, since you don’t have to look down, and it looks cleaner too.

During the 2/.5 year timespan of my slow descent into blindness, which ended up happening over 11 years ago, I found that full-screen zoom, inverted colors, and the touch surface of the Magic Mouse were a perfect combo. Dark mode wasn't really a thing back then, and I also had to negate the color codes associated with ANSI colors to keep enjoying the standard black background Unix terminal experience that I was used to while using inverted colors. While back then the smart invert colors accessibility feature was yet to be made public, resulting in all image and video content to have their colors inverted as well, temporarily disabling this feature to watch full-screen pictures or video was just a matter of pressing Control+Option+Command+8. Another setting that I used to enable was an option to make the system read out any system dialogs that popped up on the screen, so that I could be aware of them even when they were not visible in the portion of the screen that I was zooming into.

When full-screen zoom is enabled there's a special key, which was Control back then but I used to switch it to Command, that, if pressed while performing the up and down scroll gestures on a Magic Mouse or Magic Trackpad, or moving the scroll wheel or trackball on any other mouse up or down, allows zooming in and out of screen content very easily. In addition to this I also used to have the screen-reader configured to keep the mouse pointer as well as the keyboard input caret centered on the screen depending on whether I was moving the mouse or typing text. The reason why I'm praising the experience of using the Magic Mouse in particular is because its touch-based interface coupled with Apple's ubiquitous momentum scrolling design really makes the full-screen zoom experience very efficient and natural.

While the screen-reading experience on macOS is total crap, the zoom experience in particular was and might still be top notch. During the time I had to use it I never found a single reason to complain, as it felt truly enabling and light years ahead of what everyone else was doing. All Mac laptops, as well as all Mac desktops with a TouchID Apple keyboard, have two very useful accessibility shortcuts, with one being holding Control+Option while triple-pressing the TouchID sensor to bring up the accessibility menu, and the other being holding Command while triple-pressing the TouchID sensor to enable your favorite accessibility feature, which is VoiceOver in my case but can be anything else.