dragging and dropping items with voiceover from the desktop to a web area

macOS and Mac Apps

Hey everyone.
I was just wondering whether anybody could tell me if there is a way of dragging and dropping items into web areas in safari or specific websites that require drag and drop.
For example, If I want to drag and drop a file that is on my desktp to a website like my school portal that allows for drag and drop, is this possible?
If somebody could let me know a soon as possible, that would be reatly appreciated.
Thanks everyone and have a good day.