Accessible audio interfaces for iphone and mac

Hi all. I'd like to buy an audio interface for my iphone 6s plus. Since I'm interested in getting a macbook in the near future I'm looking for an audio interface for macs as well. What audio interfaces with accessible software mixers are out there? On my windows system I use an RME fireface UC, which I can only use thanks custom snapshot templates tough. So I'm really wondering if things like software mixers are accessible on IOS and OSX.
I read good things about apogee duet and quartet. Would these be accessible with VoiceOver? What else would you recommend? Cost is not an issue for me if I get professional quality and if it's accessible.
Thanks in advance and kind regards
Ben